• Christopher R Carpenter, Samuel M Keim, Suneel Upadhye, H Bryant Nguyen, and Best Evidence in Emergency Medicine Investigator Group.
• Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
• J Emerg Med. 2009 Oct 1;37(3):319-27.

BackgroundThe prompt recognition and management of septic patients remains a challenge within the busy Emergency Department (ED). Prognostic screening aids have traditionally required time-delayed laboratory measurements not validated upon the emergency medicine population. Recently, a brief prognostic tool has been derived and subsequently validated in heterogeneous ED populations.Clinical QuestionCan a risk-stratification tool predict 1-month mortality in ED patients with suspected infection?Evidence ReviewSix studies evaluating the Mortality in the Emergency Department Sepsis (MEDS) score were identified and evaluated.ResultsHigher MEDS scores are associated with increasing mortality. MEDS score's short- and long-term prognostic accuracy is superior to other sepsis scales as well as isolated biomarkers C-reactive protein and procalcitonin. MEDS' prognostic accuracy in severe sepsis is inferior to undifferentiated systemic inflammatory response syndrome (SIRS) patients.ConclusionThe MEDS score is an accurate and reliable prognostic tool for 28-day mortality in ED SIRS patients, but may not be optimal for those with severe sepsis.

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