• Anita L Kozyrskyj, Salma Bahreinian, Geoff D C Ball, Timothy K Vander Leek, Ian Colman, Brian J McNeil, and Allan B Becker.
• 3-547, Edmonton Clinic Health Academy (ECHA), 11405-87 Avenue, Edmonton, AB, T6G 1C9 Canada. bahreini@ualberta.ca
• Am. J. Respir. Crit. Care Med.. 2013 Jan 15;187(2):144-52.

RationaleAllostatic load (AL), a novel measure of the physiologically dysregulated response of the body to stress, represents a biomarker of chronic stress exposure.ObjectivesTo determine whether preadolescent children with high AL are more susceptible to asthma as adolescents.MethodsThis was a prospective evaluation of children recruited at 7 to 10 years of age in the nested case-control arm of the Study of Asthma, Genes and Environment and followed until 11 to 14 years of age. AL was measured using eight biomarkers: fasting glucose, total cholesterol, high-density lipoprotein cholesterol, dehydroepiandrosterone sulfate, cortisol, systolic and diastolic blood pressure, and waist-to-hip ratio. AL, created from the sum of biomarkers in a high-risk quartile, was related to prevalence and incidence of asthma using logistic regression.Measurements And Main ResultsAmong 352 participants followed until 11 to 14 years of age, prevalent asthma was four times more likely in boys with high (>3) versus low (≤2) AL after adjusting for current asthma/atopy, age, ethnicity, parental history of asthma, and overweight status. Similar results were observed in the analysis of new-onset asthma in boys (adjusted odds ratio, 4.35; 95% confidence interval, 1.19-15.9). In girls, there were no associations between AL and asthma. In the analysis of a subset of biomarkers, combinations of total cholesterol, glucose, and cortisol were associated with similar or greater risk of asthma prevalence or onset in boys.ConclusionsAL and its biomarkers are associated with an increased likelihood of asthma in adolescent boys. The observed association between AL and asthma may be attributable to a combined subset of AL biomarkers.

28 keywords...

hide…