• J. Thorac. Cardiovasc. Surg. · Apr 2024

    Surgical versus Transcatheter Aortic Valve Replacement in Low Risk Medicare Beneficiaries.

    • J Hunter Mehaffey, Mohammad Kawsara, Vikrant Jagadeesan, HayangaJ W AworiJWADepartment of Cardiovascular and Thoracic Surgery, West Virginia University, Morgantown, WVa., Dhaval Chauhan, Lawrence Wei, Christopher Mascio, J Scott Rankin, Ramesh Daggubati, and Vinay Badhwar.
    • Department of Cardiovascular and Thoracic Surgery, West Virginia University, Morgantown, WVa. Electronic address: James.Mehaffey@wvumedicine.org.
    • J. Thorac. Cardiovasc. Surg. 2024 Apr 28.

    ObjectiveRecent approval of transcatheter aortic valve replacement (TAVR) in patients at low surgical risk has resulted in a rapid real-world expansion of TAVR in patients not otherwise examined in recent low-risk trials. We sought to evaluate the outcomes of surgical aortic valve replacement (SAVR) versus TAVR in low-risk Medicare beneficiaries.MethodsUsing the US Centers for Medicare and Medicaid Services claims database, we evaluated all beneficiaries undergoing isolated SAVR (n = 33,210) or TAVR (n = 77,885) (2018-2020). International Classification of Diseases 10th revision codes were used to define variables and frailty was defined by the validated Kim index. Doubly robust risk adjustment was performed with inverse probability weighting and multilevel regression models, as well as competing-risk time to event analysis. A low-risk cohort was identified to simulate recent low-risk trials.ResultsA total of 15,749 low-risk patients (8144 SAVR and 7605 TAVR) were identified. Comparison was performed with doubly robust risk adjustment accounting for all factors. TAVR was associated with lower perioperative stroke (odds ratio, 0.62; P < .001) and hospital mortality (odds ratio, 0.16; P < .001) compared with SAVR. However, risk-adjusted longitudinal analysis demonstrated TAVR was associated with higher late risk of stroke (hazard ratio, 1.65; P < .001), readmission for valve reintervention (hazard ratio, 1.88; P < .001), and all-cause mortality (hazard ratio, 1.54; P < .001) compared with SAVR.ConclusionsAmong low-risk Medicare beneficiaries younger than age 75 years undergoing isolated AVR, SAVR was associated with higher index morbidity and mortality but improved 3-year risk-adjusted stroke, valve reintervention, and survival compared with TAVR.Copyright © 2024 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

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