• Sumeet Rai, Teresa Neeman, Rhonda Brown, Krishnaswamy Sundararajan, Arvind Rajamani, Michelle Miu, Rakshit Panwar, Mary Nourse, van HarenFrank M PFMPSchool of Medicine and Psychology, Australian National University, Canberra, Australia.Intensive Care Unit, St. George Hospital, Kogarah, Sydney, Australia., Imogen Mitchell, Dale M Needham, and PRICE study investigators.
• School of Medicine and Psychology, Australian National University, Canberra, Australia.
• Crit Care Resusc. 2024 Mar 1; 26 (1): 8158-15.

ObjectiveTo compare long-term psychological symptoms and health-related quality of life (HRQOL) in intubated versus non-intubated ICU survivors.DesignProspective, multicentre observational cohort study.SettingFour tertiary medical-surgical ICUs in Australia.ParticipantsIntubated and non-intubated adult ICU survivors.Main Outcome MeasuresPrimary outcomes: clinically significant psychological symptoms at 3- and 12-month follow-up using Post-Traumatic Stress Syndrome-14 for post-traumatic stress disorder; Depression, Anxiety Stress Scales-21 for depression, anxiety, and stress. Secondary outcomes: HRQOL, using EuroQol-5D-5L questionnaire.ResultsOf the 133 ICU survivors, 54/116 (47 %) had at least one clinically significant psychological symptom (i.e., post-traumatic stress disorder, anxiety, depression, stress) at follow-up. Clinically significant scores for psychological symptoms were observed in 26 (39 %) versus 16 (32 %) at 3-months [odds ratio 1.4, 95 % confidence interval (0.66-3.13), p = 0.38]; 23 (37 %) versus 10 (31 %) at 12-months [odds ratio 1.3, 95 % confidence interval (0.53-3.31), p = 0.57] of intubated versus non-intubated survivors, respectively. Usual activities and mobility were the most commonly affected HRQOL dimension, with >30 % at 3 versus months and >20 % at 12-months of overall survivors reporting ≥ moderate problems. There was no difference between the groups in any of the EQ5D dimensions.ConclusionsNearly one-in-two (47 %) of the intubated and non-intubated ICU survivors reported clinically significant psychological symptoms at 3 and 12-month follow-ups. Overall, more than 30 % at 3-months and over 20 % at 12-months of the survivors in both groups had moderate or worse problems with their usual activities and mobility. The presence of psychological symptoms and HRQOL impairments was similar between the groups.© 2023 The Authors.

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