• Arch Med Sci · Jan 2024

    Gedunin induces apoptosis and inhibits HMBG1/PI3K/AKT signaling pathways in a rat model of gastric carcinogenesis induced by methylnitronitrosoguanidine.

    • Weixiang Zhang, Yongshuai Dong, and Chenkun Sun.
    • Department of General Surgery, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong, China.
    • Arch Med Sci. 2024 Jan 1; 20 (2): 691697691-697.

    IntroductionThis study aimed to evaluate the anti-cancer effects of gedunin, a natural compound, in a rat model of gastric carcinogenesis induced by MNNG.MethodsFifty-four rats were randomly assigned to six groups for a 60-day study on the effects of MNNG and gedunin. Groups 1-4 received 200 mg/kg MNNG (1, 10, or 100 mg/kg), and group 5 had only 100 mg/kg gedunin.ResultsGedunin at low doses exhibited anti-cancer and protective properties against MNNG-induced damage, including reduced inflammation, and apoptosis.ConclusionsGedunin demonstrates a U-shaped dose-response, with low doses offering protection and high doses promoting tumor growth.Copyright: © 2024 Termedia & Banach.

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