• Intern Emerg Med · May 2024

    Review

    Drug prescription appropriateness in hospitalized older patients: 15-year results and lessons from a countrywide register.

    • Alessandro Nobili, Pier Mannuccio Mannucci, and REPOSI Investigators.
    • Department of Health Policy, Institute for Pharmacological Research Mario Negri IRCCS, Milan, Italy.
    • Intern Emerg Med. 2024 May 21.

    AbstractThe global increase of aging with the related increase of multiple noncommunicable diseases is inevitably accompanied by the associated issue of multimorbidity and polypharmacy. The latter is not without peculiar consequences on health, because it has been shown to be associated with drug-related adverse events, mainly due to poor prescription appropriateness and drug-drug interactions. To contribute to tackle this gigantic problem, a registry of drug dispensation in hospitalized older patient has been initiated in Italy in 2008. Through the last 15 years, data on nearly 11,000 older people have been accrued during their hospital stay in internal medicine and geriatric wards. This review article summarizes the main findings obtained, and how these data contribute to tackle the issue of appropriateness of drug prescription and the need of deprescribing in hospitalized older people affected by the most common noncommunicable diseases.© 2024. The Author(s), under exclusive licence to Società Italiana di Medicina Interna (SIMI).

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