• Yujie Zhang, Jing Yang, Mingfang Zhang, Zhaowei Meng, Wenjing Song, Long Yang, Liming Li, Dan Wang, and Tao Shi.
• Department of Pathology, Tianjin Medical University General Hospital Department of Pathology, Tianjin Medical University Department of Pathology, Tianjin First Center Hospital Department of Nuclear Medicine Department of Urinary Surgery, Tianjin Medical University General Hospital, Tianjin, China.
• Medicine (Baltimore). 2018 May 1; 97 (21): e10815e10815.

RationaleThyroid follicular carcinoma-like renal tumor (TFCLRT) is a rare primary renal epithelial tumor that was first reported in 2006. We report a case diagnosed of TFCLRT by us to observe the pathological feature and analyze comparatively the clinical and pathologic characteristics with all cases of reviewed literatures.Patient ConcernsA 54-year-old female patient had the urinary frequency with the symptom of right flank pain with a history of more than half a year of hypertension and received uterine fibroid resection 12 years ago. B-mode ultrasound examination and renal magnetic resonance showed a right renal sinus nodule.DiagnosesHistopathology revealed thyroid follicle-like structures of different sizes, containing a colloid-like substance, while the periodic acid-Schiff (PAS) and diastase-resistant PAS staining confirmed that it was mucus protein. Immunohistochemical staining showed that it expresses the transcription factor PAX-8 but does not express the thyroid-specific antibodies TG and TTF-1.InterventionsThe patient underwent a tumor enucleation of right kidney. No other treatment was conducted after surgery.OutcomesNo metastases to lymph nodes and other organs were found, and 9-months of follow-up did not reveal any tumor progression.LessonsWe should differentially diagnose the renal metastasis of thyroid follicular carcinoma or papillary carcinoma. Some related literatures reported that the tumour cells had significant heteromorphism, several of which metastasized to lymph nodes or distal organs. Its biological behavior need to be studied intensively by further expanding the number of cases.

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