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- Marcin Goławski, Mateusz Lejawa, Maciej Banach, Jacek Jóźwiak, Marek Gierlotka, and Tadeusz Osadnik.
- Department of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland.
- Arch Med Sci. 2024 Jan 1; 20 (3): 100210051002-1005.
IntroductionBlood lipoprotein(a) (Lp(a)) levels have been observed to be inversely correlated with type 2 diabetes (T2D). In this Mendelian randomization (MR) study, the causal impact of genetically predicted Lp(a) on T2D was assessed.MethodsA two-sample MR analysis was conducted. Data were obtained from UK Biobank and FinnGen consortia. Primary analysis was based on an inverse-variance-weighted mean (IVM) approach.ResultsNo statistically significant association between the genetically predicted levels of Lp(a) and T2D was detected (p = 0.362) in IVM analysis involving data of 563,420 patients.ConclusionsGenetically predicted Lp(a) concentration does not appear to be causally related to the risk of T2D.Copyright: © 2024 Termedia & Banach.
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