• Xiuyuan Ni, Shigeng Zhou, Congling Wang, Shengheng Chen, Jingdan Hu, and Shengjing Zhang.
• Xiuyuan Ni Department of Respiratory, Wenzhou Geriatric Hospital, Wenzhou city, Zhejiang Province 325000, P.R. China.
• Pak J Med Sci. 2024 Aug 1; 40 (7): 139113961391-1396.

ObjectiveTo explore the clinical value of Vitamin-D combined with budesonide/formoterol (BF) and theophylline sodium glycinate (TSG) sustained-release tablets in the treatment of patients with chronic obstructive pulmonary disease (COPD).MethodsMedical records of 114 patients with CODP, treated in Wenzhou Geriatric Hospital from October 2020 to February 2023, were retrospectively analyzed. Of them, 59 received treatment with Vitamin-D combined with BF and TSG sustained-release tablets (Group-A), and 55 patients received treatment with BF combined with TSG sustained-release tablets (Group-B). Lung function indicators, blood gas status, inflammatory factors, fractional exhaled nitric oxide (FeNO), and 25-hydroxyvitamin D [25(OH)D] levels before and after the treatment in both groups were collected.ResultsAfter the treatment, lung function indicators, blood gas status, inflammatory factors, FeNO, and 25 (OH) D levels in both groups were significantly improved compared to pretreatment levels, and were significantly better in the Group-A compared to Group-B (P<0.05).ConclusionsThe combination of Vitamin-D, BF, and TSG sustained-release tablets can effectively regulate the blood gas status of patients with COPD, improve lung function, regulate FeNO and 25 (OH) D, and effectively downregulate the levels of inflammatory factors, thus reducing the degree of inflammatory response.Copyright: © Pakistan Journal of Medical Sciences.

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