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- Kengo Suzuki, Daisuke Koyama, Shoki Yamada, Yuka Oka, Kiyohito Hayashi, Yasuhiro Uchida, Yuki Sato, Yuko Hashimoto, and Takayuki Ikezoe.
- Department of Hematology, Fukushima Medical University, Japan.
- Intern. Med. 2024 Oct 18.
AbstractPlasmablastic lymphoma (PBL) is an aggressive subtype of large B-cell lymphoma associated with immunodeficient states, such as HIV and EBV infections, and aging. PBL frequently harbor STAT3 mutations, which are crucial for their development. We herein report a rare case of PBL complicated by T-cell large granular lymphocytic leukemia (T-LGLL) and pure red cell aplasia (PRCA). The patient was treated with six cycles of chemotherapy and developed transfusion-dependent anemia. Large granular lymphocytes and T-cell receptor rearrangement were detected, thus leading to the diagnosis of T-LGLL and PRCA. This is the first documented case of PBL with T-LGLL and PRCA, offering insight into PBL's pathophysiology and the complications of PBL.
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