-
- Takashi Matsumura, Kenji Tsuchihashi, Takeo Yamamoto, Fumiaki Jinnouchi, Wataru Kusano, Yota Kusumoto, Kohei Arimizu, Hirofumi Ohmura, Yuki Kuma, Shohei Moriyama, Kyoko Yamaguchi, Mamoru Ito, Taichi Isobe, Hiroshi Ariyama, Yoshinao Oda, Koichi Akashi, and Eishi Baba.
- Department of Hematology, Oncology and Cardiovascular Medicine, Kyushu University Hospital, Japan.
- Intern. Med. 2024 Oct 18.
AbstractA 75-year-old man diagnosed with esophageal cancer and lung metastasis received a combination of fluorouracil, cisplatin, and pembrolizumab. During pembrolizumab maintenance therapy, lymphoproliferative lesions at the lips and mouth and multiple lymph node swellings appeared. Histologically, Epstein-Barr virus (EBV)-encoded RNA was positive, and EBV-DNA was detected in the blood. The patient was diagnosed with other iatrogenic immunodeficiency-associated lymph proliferative disorders (OIIA-LPDs) related to EBV activation induced by pembrolizumab. Rituximab was administered, resulting in the improvement of the OIIA-LPD. The emergence of an OIIA-LPD merits close attention in patients receiving immune checkpoint inhibitors.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..