• Zijing Zhou, Wei Cheng, Cong Liu, Qing Song, Ling Lin, Yuqin Zeng, Dingding Deng, Libing Ma, Zhiping Yu, Rong Yi, and Ping Chen.
• Department of Pulmonary and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Renmin Middle Road, No. 139, Changsha, 410011, Hunan, China.
• J Gen Intern Med. 2024 Oct 1.

BackgroundThe prediction capacity of the Clinical COPD Questionnaire (CCQ) and its functional, symptom, and mental subdomain for COPD hospitalized exacerbation were rarely studied.ObjectiveTo examine the prognostic capacity of the total CCQ and its three subdomains for 3-year COPD hospitalized exacerbations.MethodsWe analyzed the predictive ability of total CCQ score and its subdomains for hospitalized exacerbations in an observational cohort of 987 subjects with stable COPD from the RealDTC, an ongoing multicenter prospective study. Hospitalized exacerbations were prospectively collected every 6 month for a maximum of 3 years.ResultsThe total CCQ and its functional and symptom domain, but not the mental domain, were significantly associated with 3-year hospitalized exacerbations by multivariate Cox regression analysis. The predictive capacity of functional domain was similar to that of the total CCQ, but significantly stronger than the symptom and mental domain by ROC analysis (P < 0.05). ROC curves also showed that the AUC of exacerbation history combined with CCQ functional domain was larger than that of exacerbation history alone (P < 0.0001). Additionally, the predictive value of multivariable models that contains CCQ functional domain was significantly better than the corresponding model without CCQ functional domain (P < 0.05).ConclusionsThe total CCQ and its functional and symptom domain were independent risk factors of 3-year hospitalized exacerbations. The prognostic capacity of the functional domain was similar to that of total CCQ, and was significantly stronger than the symptom and mental domain. The CCQ functional domain was able to increase the predictive power of exacerbation history and other multivariable prediction models, indicating it may have an important role in the multivariable prediction tool for hospitalized exacerbation, and its combination with other clinical variables might be used as a low-cost approach for assessments of the disease severity and severe exacerbation in COPD patients in the future.© 2024. The Author(s), under exclusive licence to Society of General Internal Medicine.

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