• Parviz Kashefi, Saeed Abbasi, Koosha Kiani, Maryam Khalifehsoltani Khajoei, and Mojtaba Akbari.
• Department of Anesthesia and Intensive Care, Alzahra University Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
• J Res Med Sci. 2024 Jan 1; 29: 4848.

BackgroundApnea testing is mandatory to confirm brain death; however, it is unsafe for patients who have substantial hypoxemia without ventilator support. We used a new modified apnea test without the need to disconnect the patient from the ventilator in the present study and compared the outcomes and complications of the new method to the widely used old method.Materials And MethodsThe current study was conducted on people suspected of having brain death. Both the old and new apnea tests were carried out on the same individual. In the new modified method, instead of hyperventilating and then separating the brain death from the ventilator, the induced hypercapnia method was used, and instead of performing repeated arterial blood gas (ABG), the target ETCO2 was obtained, and at the time of the target ETCO2, ABG was also checked followed by comparing ETCO2 with PaCO2.ResultsThirty patients, including 25 (83.3%) males and 5 (16.75%) females, were included in the study. The results showed significant improvement in terms of O2 saturation and heart rate (HR) using the new modified apnea test compared to the common test. Systolic blood pressure, diastolic blood pressure, and the frequency of complications were improved in the new modified test.ConclusionThe modified apnea test produced better results in terms of O2 saturation, HR, and other clinical factors, while it does not require disconnection from the ventilator and repeated ABG assessment. Therefore, it can be used to successfully diagnose brain death in high-risk individuals suffering from severe hypoxia.Copyright: © 2024 Journal of Research in Medical Sciences.

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