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- Robert J Lamberts, Hanno L Tan, Quinten H Leijten, Josemir W Sander, and Roland D Thijs.
- Stichting Epilepsie Instellingen Nederland (SEIN), afd. Neurologie, Heemstede.
- Ned Tijdschr Geneeskd. 2013 Jan 1;157(48):A6193.
AbstractSudden unexpected death in epilepsy (SUDEP) is the most important direct epilepsy-related cause of death. Patients with refractory epilepsy are at especially high risk of SUDEP. SUDEP occurs predominantly at night and unwitnessed, and can best be regarded as a fatal tonic-clonic seizure. While its pathophysiology is incompletely understood, SUDEP is most probably triggered by a number of predisposing and precipitating factors, including seizure-induced respiratory depression and cardiac arrhythmia. Achieving seizure freedom is the best way to prevent SUDEP. Nocturnal supervision may be another alternative preventive strategy, but this requires further research.
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