• Iryna Voronkina, Adriana Liptakova, Valentina Dyachenko, Svetlana Derkach, and Nadejda Sklyar.
• Bratisl Med J. 2024 Jan 1; 125 (11): 728733728-733.

BackgroundThe goal of our work was to develop a composition for antimicrobial photodynamic inactivation (aPDI) of anaerobic periodontopathogenic pathogens.MethodsThe three test groups were as follows: light plus doxycycline (L+DOX+), light plus doxycycline and hypericin (L + DOX + HYP +), and control groups. aPDI was evaluated by the number of grown colonies on a dense nutrient medium after 12, 24, and 48 hours of bacterial suspension cultivation.ResultsBased on the results of microbiological studies, the combined photosensitising effect of a subinhibitory dose of doxycycline and hypericin was determined. The delay of growth of A. israelii, P. melaninogenica in the second group (L+DOX+HYP) was significantly significant compared to the first group (L+DOX+), and the statistical difference in colony formation activity was found for both gram-positive and gram-negative cultures (p<0.05).ConclusionsaPDT is a promising therapeutic alternative for the local treatment of purulent-inflammatory diseases of various localisation caused by antibiotic-resistant bacteria, including in the oral cavity (Fig. 3, Ref. 57). Text in PDF www.elis.sk Keywords: peri-implant diseases, photodynamic therapy, photosensitiser, anaerobic bacteria.

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