• Br J Anaesth · Feb 2025

    Editorial Review

    Nonsteroidal anti-inflammatory drugs in the perioperative period: current controversies and concerns.

    • Girish P Joshi, Henrik Kehlet, and Dileep N Lobo.
    • Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: girish.joshi@utsouthwestern.edu.
    • Br J Anaesth. 2025 Feb 1; 134 (2): 294296294-296.

    AbstractNonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase (COX)-2-specific inhibitors provide significant analgesic and opioid-sparing benefits. However, these analgesics are commonly avoided owing to concerns of potential adverse effects. The evidence for NSAID-related adverse effects is conflicting and of poor quality, and these analgesics are safer than what has been implied. Thus, it is imperative that NSAIDs or COX-2-specific inhibitors are administered routinely unless there are well-founded contraindications.Copyright © 2024 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.

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