• J. Intern. Med. · Dec 2008

    Review

    Autoimmune and inflammatory disorders and risk of malignant lymphomas--an update.

    • K E Smedby, J Askling, X Mariette, and E Baecklund.
    • Department of Medicine, Clinical Epidemiology Unit, Karolinska University Hospital, Stockholm, Sweden. karin.ekstrom.smedby@ki.se
    • J. Intern. Med. 2008 Dec 1; 264 (6): 514527514-27.

    AbstractAs specific autoimmune disorders now constitute established risk factors for malignant lymphomas, we describe this association. We review reported risk levels, risk determinants, lymphoma subtypes and biological mechanisms in autoimmunity/inflammation, emphasizing on recent findings. Whilst numerous reports describe average lymphoma risks in large patient groups, there's a recent shift of focus to risk determinants and the role of inflammatory activity. Studies highlight associations with diffuse large B-cell lymphoma, apart from lymphoma development in target organs of inflammation. Future studies of high-risk patient subsets using detailed assessments of autoimmunity/inflammation and lymphoma may give important clues to lymphomagenesis.

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