• Int. J. Clin. Pract. · Dec 2005

    Randomized Controlled Trial Multicenter Study

    Lipid-altering efficacy of switching from atorvastatin 10 mg/day to ezetimibe/simvastatin 10/20 mg/day compared to doubling the dose of atorvastatin in hypercholesterolaemic patients with atherosclerosis or coronary heart disease.

    • V Barrios, N Amabile, F Paganelli, J-W Chen, C Allen, A O Johnson-Levonas, R Massaad, and K Vandormael.
    • Department of Cardiology, Hospital Ramón y Cajal, Madrid, Spain. vbarrios.hrc@salud.madrid.org
    • Int. J. Clin. Pract. 2005 Dec 1; 59 (12): 137713861377-86.

    AbstractThis randomised, double-blind study evaluated the efficacy and safety of ezetimibe/simvastatin (EZE/SIMVA) 10/20 mg tablet compared to doubling the atorvastatin (ATV) dose in hypercholesterolaemic patients with atherosclerotic or coronary heart disease (CHD). The study group included 435 male and female CHD patients (aged >or=18 years) who had not achieved their low-density lipoprotein cholesterol (LDL-C) goal of <2.50 mmol/l while on a stable dose of ATV 10 mg for >or=6 weeks. After a 1-week diet/stabilisation period, patients with LDL-C >or=2.50 mmol/l and

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