• Internal medicine · Jan 2010

    Case Reports

    Long-term survival of a patient with splenic angiosarcoma after resection, high-dose chemotherapy, and autologous peripheral blood stem cell transplantation.

    • Takeshi Hara, Hisashi Tsurumi, Senji Kasahara, Kengo Ogawa, Jun Takada, Kenji Imai, Koji Takai, Jun-ichi Kitagawa, Shigeru Kiyama, Naoki Imai, Masami Oyama, Tsuyoshi Takami, and Hisataka Moriwaki.
    • The First Department of Internal Medicine, Gifu University Graduate School of Medicine.
    • Intern. Med. 2010 Jan 1; 49 (20): 225322572253-7.

    AbstractA 48-year-old woman was admitted to our hospital in 2003, complaining of weight loss. Complete blood cell count revealed thrombocytopenia. Abdominal CT demonstrated marked splenomegaly. FDG-PET revealed a hot spot in the whole spleen. A splenectomy was performed. Histological examination was typical for angiosarcoma. Adjuvant chemotherapy was given, and high-dose chemotherapy with autologous peripheral blood stem cell transplantation was performed. Thrombocytopenia developed again in 2008. CT scan showed a hepatic tumor. A fine-needle biopsy of the liver revealed the first relapse. Despite hepatic lobectomy, radiofrequency ablations and administration of recombinant interleukin-2, she died from respiratory failure in 2009.

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