• Internal medicine · Dec 2024

    Concomitant Interstitial Pneumonia and Disseminated BCG Infection after Intravesical BCG Therapy: A Case Report.

    • Fumi Mochizuki, Midori Hanazawa, Manabu Komine, Hiroya Sunabe, Sayumi Koyanagi, Yuki Yamazaki, Ayumi Watanabe, Takafumi Shimada, Kazuki Obara, Hiroaki Iijima, Koichi Kurishima, and Hiroichi Ishikawa.
    • Department of Respiratory Medicine, Tsukuba Medical Center Hospital, Japan.
    • Intern. Med. 2024 Dec 19.

    AbstractAn 83-year-old man presented with persistent fever after intravesical BCG therapy for bladder cancer. Chest computed tomography (CT) and bronchoscopy revealed diffuse ground-glass opacities with multiple micronodules and lymphocyte-predominant bronchoalveolar lavage fluid with a high CD4/CD8 ratio, respectively. Therefore, corticotherapy for interstitial pneumonia was initiated. Anti-fast staining of the respiratory specimens was negative; however, anti-tuberculosis treatment was added based on CT findings suggesting disseminated BCG infection. Fifty days post-admission, Mycobacterium bovis BCG was identified in the initial sputum cultures. Concomitant interstitial pneumonia and BCG infection should be considered in patients with abnormal chest imaging following intravesical BCG therapy.

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