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- Kenta Ishii, Hisashi Takahashi, Misaki Kubota-Hanya, Rei Yasuda, Fumitoshi Niwa, Masaki Kondo, and Toshiki Mizuno.
- Department of Neurology, North Medical Center, Kyoto Prefectural University of Medicine, Japan.
- Intern. Med. 2024 Dec 19.
AbstractA 63-year-old previously healthy man participated in a longitudinal epidemiologic study of dementia and aging. Although he initially showed no subjective symptoms and a normal motor function, verbal fluency test scores gradually declined, and progressive atrophy of the frontal lobes was observed on magnetic resonance imaging of the head. At 71 years old, progressive supranuclear palsy (PSP) was diagnosed after supranuclear gaze palsy, and gait disturbance developed. This longitudinal epidemiological study suggests that verbal symptoms and mild frontal lobe atrophy may be evident in the premotor phase of PSP.
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