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- Naohiro Itoh, Kenji Kasuno, Motoko Yasutomi, Shohei Kamekawa, Izumi Itoh, Taihei Hayashi, Tatsushi Naito, Yoshiaki Imamura, Yasunari Nakamoto, and Yusei Ohshima.
- Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Japan.
- Intern. Med. 2024 Dec 19.
AbstractGranulomatous interstitial nephritis (GIN) has been reported in <0.5% of patients with inflammatory bowel disease, and most cases of GIN are drug-induced. A 13-year-old boy was referred for the evaluation of abdominal pain, diarrhea, and weight loss. The patient was diagnosed with non-drug-induced GIN and Crohn's disease based on total colonoscopy and a biopsy of the colon and kidney. Both tissues contained macrophages and increased epithelial expression of IκBζ, a protein involved in the NF-κB pathway. There may be more patients with GIN complicated by Crohn's disease than expected, and macrophages may be involved in the pathogenesis.
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