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- Jun Wada, Kazumasa Kawashima, Michio Onizawa, Naohiko Gunji, Yu Watahiki, Chiharu Sakuma, Mai Murakami, Tomoaki Mochimaru, Shunsuke Miura, and Hiromasa Ohira.
- Department of Gastroenterology, Fukushima Medical University School of Medicine, Japan.
- Intern. Med. 2024 Dec 26.
AbstractMesalazine-induced pericarditis is rare, and most cases occur at the time of treatment initiation. A 30-year-old man with ulcerative colitis who had experienced remission for 2 years with mesalazine 2,000 mg/day subsequently experienced relapse. Therefore, the mesalazine dose was increased to 4,000 mg. Thereafter, hematochezia improved, but anterior chest pain developed. Chest radiography revealed marked cardiac dilation (cardiothoracic ratio, 63%) and echocardiography revealed pericardial effusion. Adverse events associated with mesalazine should be carefully monitored, not only at the time of treatment initiation but also after dose escalation.
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