• Internal medicine · Dec 2024

    Diffuse Large B-cell Lymphoma with a Multilobated Nuclear Morphology Harboring t (14;18) (q32;q21) and t (3;22) (q27;q11): A Case Report.

    • Masahiro Manabe, Naoyuki Inano, Yuuji Hagiwara, and Ki-Ryang Koh.
    • Department of Hematology, Osaka General Hospital of West Japan Railway Company, Japan.
    • Intern. Med. 2024 Dec 26.

    AbstractA 70-year-old woman was admitted to our hospital with dyspnea. Atypical cells with multilobated nuclei were observed in the pleural effusion. Diffuse large B-cell lymphoma (DLBCL) was diagnosed based on a cell block analysis. A chromosomal analysis of lymphoma cells revealed t (14;18) (q32;q21) and t (3;22) (q27;q11). The patient's disease was refractory to chemotherapy, and she died within one year. Although flower-like nuclei are typical of adult T-cell lymphoma/leukemia, similar multilobated nuclei may occur in DLBCL. Although multilobated DCBCL have been reported to have a better prognosis than other forms of DLBCL, the abovementioned translocations may have contributed to the patient's aggressive clinical course.

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