• Yunji Hwang, Kyu Eun Lee, Young Joo Park, Su-Jin Kim, Hyungju Kwon, ParkDo JoonDJ, Belong Cho, Ho-Chun Choi, Daehee Kang, and Sue K Park.
• From the Department of Preventive Medicine (YH, DK, SKP), Seoul National University College of Medicine; Department of Biomedical Science (YH, DK, SKP), Seoul National University Graduate School; Cancer Research Institute (YH, KEL, DK, SKP), Seoul National University College of Medicine; Department of Surgery (KEL, S-JK, HK), Seoul National University Hospital and College of Medicine; Division of Surgery (KEL), Thyroid Center, Seoul National University Cancer Hospital; Department of Internal Medicine (YJP, DJP), Seoul National University College of Medicine; Department of Family Medicine (BC, H-CC), Health Promotion Center for Cancer Survivor, Seoul National University Hospital, Seoul; and Advanced Institutes of Convergence Technology (BC, H-CC), Seoul National University, Suwon-si, Gyeonggi-do, Korea.
• Medicine (Baltimore). 2016 Mar 1; 95 (9): e2893e2893.

AbstractWe evaluated the association between weight change in middle-aged adults and papillary thyroid cancer (PTC) based on a large-scale case-control study. Our study included data from 1551 PTC patients (19.3% men and 80.7% women) who underwent thyroidectomy at the 3 general hospitals in Korea and 15,510 individually matched control subjects. The subjects' weight history, epidemiologic information, and tumor characteristics confirmed after thyroidectomy were analyzed. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were determined for the annual average changes in weight and obesity indicators (body mass index (BMI), body surface area, and body fat percentage (BF%) in subjects since the age of 35 years. Subjects with a total weight gain ≥10 kg after age 35 years were more likely to have PTC (men, OR, 5.39, 95% CI, 3.88-7.49; women, OR, 3.36, 95% CI, 2.87-3.93) compared with subjects with a stable weight (loss or gain <5 kg). A marked increase in BMI since age 35 years (annual average change of BMI ≥0.3 kg/m/yr) was related to an elevated PTC risk, and the association was more pronounced for large-sized PTC risks (<1 cm, OR, 2.34, 95% CI, 1.92-2.85; ≥1 cm, OR, 4.00, 95% CI, 2.91-5.49, P heterogeneity = 0.005) compared with low PTC risks. Weight gain and annual increases in obesity indicators in middle-aged adults may increase the risk of developing PTC.

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