• Signe Voss Vahlkvist, Mercedes Romano Rodriguez, Mikkel Pedersen, and Thomas Houmann Petersen.
• Department of Pediatrics and Adolescent Medicine, Lillebaelt Hospital, University Hospital of Southern Denmark, Kolding, Denmark.
• Curr Med Res Opin. 2025 Jan 31: 181-8.

ObjectiveThe symptom burden associated with allergic rhinitis (AR) negatively impacts the life of people living with the condition. Although the impact of AR on educational outcomes and the effect of AR-relieving medication have been investigated, the availability of up-to-date, population-based, real-world evidence is limited. Therefore, the aim was to investigate the impact of AR and AR-relieving medication on educational outcomes.MethodsA register-based study was conducted using Danish registers. Educational outcomes were defined as the average 9th-grade final grade. Individuals diagnosed with AR before the age of 13, born between 1986 and 2006, and with observed final examination grades were included as cases. To investigate the impact of AR-relieving medication, cases were stratified by medication use. The impact of AR was estimated through a comparison of individuals with AR to their sibling with no history of AR.Results52,808 cases were included (33,035 with siblings). Cases with no filled prescriptions of AR-relieving medication in their final examination year had an average grade of 7.09. Cases with a minimum of one collection had a higher average. Cases initiated on AIT had an average test score that was 0.60 points higher than cases with no filled prescriptions of aH or INCs in the final examination year. The average grade among cases with paired siblings was 7.29 whilst their siblings had an average grade that was -0.04 lower.ConclusionIn the Danish context, AR does not affect educational outcomes; however, more frequent use of AR-relieving medications is associated with better educational outcomes.

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