• Internal medicine · Jan 2025

    Extensive but Steroid-sensitive Pulmonary Infiltration by Natural Killer-large Granular Lymphocytic Leukemia.

    • Masahiro Tokunaga, Satoshi Tetsumoto, Hayato Maruoka, Akito Miyazaki, Shinichi Yoshikawa, and Tetsuo Maeda.
    • Department of Hematology, Suita Municipal Hospital, Japan.
    • Intern. Med. 2025 Jan 15.

    AbstractA 51-year-old woman with persistent proliferation of natural killer (NK) cells in her peripheral blood was diagnosed with NK-large granular lymphocytic leukemia (NK-LGLL). During follow-up, computed tomography revealed multiple infiltrative pulmonary lesions. A flow cytometric analysis of bronchoalveolar lavage fluid showed infiltration of NK cells, resulting in a diagnosis of pulmonary infiltration by NK-LGLL. A histological examination of thoracoscopic lung biopsy specimens supported this diagnosis. She was started on 1 mg/kg prednisolone, which resulted in a durable reduction in these lesions. This is the first report of a NK-LGLL patient with pulmonary infiltration who received medication. Furthermore, treatment with prednisolone alone was successful.

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