• Diego Moncada-Gutiérrez, Gustavo Adolfo Vásquez-Tirado, Edinson Dante Meregildo-Rodríguez, Claudia Vanessa Quispe-Castañeda, María Cuadra-Campos, Percy Hernán Abanto-Montalván, Wilson Marcial Guzmán-Aguilar, Leslie Jacqueline Liñán-Díaz, Hugo Nelson Alva-Guarniz, and Luis Ángel Rodríguez-Chávez.
• Facultad de Medicina Humana, Universidad Privada Antenor Orrego, Trujillo, Perú.
• Eur J Trauma Emerg Surg. 2025 Jan 24; 51 (1): 3333.

IntroductionSepsis is a systemic process that refers to a deregulated immune response of the host against an infectious agent, involving multiple organ dysfunction. It is rapidly progressive and has a dismal prognosis, with high mortality rates. For this reason, it is necessary to have a tool for early recognition of these patients, with the aim of treating them appropriately in a timely manner.MethodsThis research is a systematic review based on bibliography indexed in four online scientific databases for studies published since inception to February 2024, which was obtained through the use of a search strategy. Eight studies were identified for quantitative analysis and included in our meta-analysis.ResultsThe meta-analysis revealed that among 23,551 patients diagnosed with sepsis, 5,825 had a positive LqSOFA, and 3,086 experienced the primary outcome (mortality). For LqSOFA, a sensitivity of 0.61 (95% CI 0.60-0.63), specificity of 0.81 (95% CI 0.80-0.81), positive likelihood ratio (LR+) of 3.46 (95% CI 2.86-4.18), negative likelihood ratio (LR-) of 0.47 (95% CI 0.38-0.59), and odds ratio (OR) of 7.43 (95% CI 6.01-9.20) were determined. The area under the curve (AUC) was 0.807.ConclusionsThe LqSOFA score demonstrates a good predictive capacity for in-hospital mortality in septic patients, showing clinically significant levels of sensitivity (69%) and specificity (79%).© 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.

15 keywords...

hide…