• Clinics · Jan 2025

    Metabolomics in juvenile idiopathic arthritis: A distinct profile in patients under methotrexate.

    • Renato B Tomioka, Gabriela R V Ferreira, Nadia E Aikawa, Gustavo A R Maciel, José M Soares Junior, Edmund C Baracat, Eloisa Bonfá, da SilvaIsmael Dale Cotrim GuerreiroIDCGDepartament of Gynecology, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, SP, Brazil., and Clovis Almeida da Silva.
    • Division of Rheumatology, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil; Discipline of Gynecology, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil. Electronic address: renato.tomioka@vidabemvinda.com.br.
    • Clinics (Sao Paulo). 2025 Jan 28; 80: 100522100522.

    AbstractThe objective of the present study was to evaluate biochemical quantitative metabolites in peripheral blood serum samples of Juvenile Idiopathic Arthritis (JIA) patients and healthy controls. A cross-sectional study included 33 post-pubertal JIA (21 without and 12 with Methotrexate (MTX) women and 28 age-matched healthy controls. Metabolomic analyses based on targeted electrospray ionization tandem mass spectrometry were used to identify possible biochemical pathway modifications in serum from JIA patients. The mean current age (p = 0.065) was similar in JIA patients and healthy controls. Current MTX use in all subtypes of JIA patients was associated with an increase in concentrations of free carnitine [21.74 (12.7‒35.2) vs. 27.49 (14.5‒41.3) µM/L, p = 0.02], suggesting an enhanced mitochondrial metabolism and intestinal absorptive function. In contrast, a decreased mitochondrial metabolism was observed in polyarticular and systemic JIA subtypes, with a decrease of several acylcarnitines' concentrations (p < 0.05). In conclusion, the present study identified a distinctive pattern of serum metabolic signatures in JIA patients under MTX therapy. Our findings indicate that MTX use is associated with a more efficient mitochondrial function.Copyright © 2024 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.

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