• J Res Med Sci · Jan 2024

    Predictive value of gemstone spectral imaging for chemotherapy response in colorectal cancer liver metastases: A retrospective study.

    • Hou-Fa Ning, Yun-Long Qin, Kui-Tao Yue, Shuai Wang, Wei-Guang Shao, and Guang-Zhi Wang.
    • Department of Medical Imaging Center, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong, China.
    • J Res Med Sci. 2024 Jan 1; 29: 7676.

    BackgroundAccurate and timely assessment of tumor response after chemotherapy is crucial in clinical settings. The aim of this study was to explore the feasibility of Gemstone Spectral Imaging (GSI) for early assessment of chemotherapy responses in patients with colorectal cancer liver metastasis (CRCLM).Materials And MethodsFrom October 2012 to October 2018, 46 patients (28 males and 18 females) with CRCLM received GSI followed by chemotherapy were retrospectively reviewed. The patients were divided into a response group (n = 32) and a nonresponse group (n = 14) according to the tumor response to chemotherapy. The iodine concentration images and virtual monoenergetic images (VMIs) with an optimal contrast-to-noise ratio at the arterial phase (AP) and portal venous phase (PVP) were obtained by GSI viewer. The iodine concentration value and computed tomography (CT) value on VMIs and slope of spectral attenuation curves of all lesions were compared. A logistic regression analysis was used to determine the predictor of chemotherapy response.ResultsThe difference of extrahepatic metastasis (P = 0.001), CT value on 68 keV VMIs at the AP (P = 0.005) and PVP (P = 0.001), slope of CT value attenuation curves at the AP (P = 0.013) and PVP (P = 0.001), and iodine concentration value at PVP (P = 0.003) between the response and nonresponse groups were statistically significant. The CT value of the 68 keV VMIs (OR: 1.206; 95% confidence interval [CI]: 1.021-1.425, P = 0.027) and the iodine concentration value at PVP (OR: 1.952; 95% CI: 1.034-3.684, P = 0.039) were independent prognostic factors for predicting chemotherapy response.ConclusionBaseline GSI may help predict the response to chemotherapy and provide a good tumor-response indicator through single-energy CT value of 68 keV at the PVP and iodine concentration.Copyright: © 2024 Journal of Research in Medical Sciences.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…