• Internal medicine · Feb 2025

    A Rare Case of Interleukin-6-producing Adrenocortical Carcinoma Presenting with a Persistent Fever.

    • Kohei Oguni, Yukiko Goshima, Keita Tatsushima, Michikata Hayashida, Shinji Urakami, Shinji Ito, Yuto Yamazaki, Hironobu Sasano, Yasuhiro Takeuchi, and Akira Takeshita.
    • Department of Endocrinology and Metabolism, Toranomon Hospital, Japan.
    • Intern. Med. 2025 Feb 1.

    AbstractA 16-year-old girl presented with a high fever that had persisted for more than 4 weeks. Computed tomography (CT) revealed a 4-cm mass in the left adrenal gland. Clinically, there were no obvious symptoms of adrenal hormone excess; however, serum interleukin-6 (IL-6) and C-reactive protein levels were significantly elevated. After laparoscopic left adrenalectomy, the fever subsided, and her IL-6 level normalized. The tumor was pathologically diagnosed as adrenocortical carcinoma (ACC), with a Weiss score of 5/9. The tumor cells were immunoreactive for IL-6. To our knowledge, this is the first case report of symptomatic IL-6-producing ACC that initially presented with a persistent fever.

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