• Mahdieh Khodaei, Eric Parent, Lawrence H Le, Sarah Hryniuk Southon, Kyle Stampe, and Edmond Lou.
• University of Alberta, Edmonton, AB, T6G 2R3, Canada.
• Eur Spine J. 2025 Feb 4.

PurposeTo determine the association of the ultrasound reflection coefficient index and other clinical parameters to predict curve progression in children with AIS.MethodsSixty-six females (13.9 ± 1.5 years old) under observation with baseline Cobb angle (24.4 ± 10.4°) consented and participated. Besides the standard clinical procedures, all participants were scanned by an ultrasound (US) imager in a standing position. All participants had been followed, and the average follow-up visit was 7.5 ± 3.1 months. Five parameters were investigated, including the Cobb angle and the Risser sign measured from the radiographs, and the kyphotic angle (KA), the axial vertebral rotation (AVR), and the reflection coefficient (RC) index measured from the ultrasonographs. The curve was considered progressed when the Cobb angle measured on two consecutive radiographs was increased by more than 5°.ResultsAmong the 5 parameters, the KA, RC index, and Risser sign were found to be significantly associated with progression (p < 0.05). Children who had KA ≤ 38° and RC ≤ 0.06 showed higher chances of progression (62%) versus children with KA > 38° and RC > 0.06.ConclusionThis pilot study showed that curve progression is associated with the Risser sign, KA, and RC index. Other parameters and a more extensive clinical study should be combined to develop a higher-accuracy prediction model.© 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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