• Zhiyong Wang, Jie Zhang, Jing Zhao, Yaxuan Wu, Shiya Zhang, Chengfen Yin, Xinjing Gao, and Lei Xu.
• Department of Critical Care Medicine, Tianjin Third Central Hospital, No. 83, Jintang Road, Hedong District, Tianjin, 300170, China. waizh1018@126.com.
• Crit Care. 2025 Feb 4; 29 (1): 6060.

BackgroundPassive leg raising (PLR) is a well-recognized method for assessing volume responsiveness in the intensive care unit (ICU); however, it has some limitations. The physiology of the cardiac preload induced by the Trendelenburg position and PLR is similar. The Trendelenburg position can be initiated from the supine position and then tilted downward (TRENDSUPINE) or from the reverse Trendelenburg position and then tilted further downward (TRENDrTREND). Therefore, this study aimed to compare the predictive performance of the percentage change in stroke volume index (ΔSVI) induced by TRENDSUPINE, TRENDrTREND, and PLR for volume responsiveness in mechanically ventilated patients in the ICU.MethodsThe study was a prospective single-center cohort study conducted in a comprehensive ICU. The study consisted of the following sequential steps: (1) baseline-1: supine position with a 0° bed angulation; (2) Trendelenburg position: 15° downward bed angulation; (3) baseline-2: the same position as baseline-1; (4) reverse Trendelenburg position: 15° upward bed angulation; (5) Trendelenburg position: 15° downward bed angulation; (6) baseline-3: the same position as baseline-1; (7) semi-recumbent position: trunk elevated at 45°; (8) PLR: lower limbs elevated at 45° and trunk in the supine position; (9) baseline-4: the same position as baseline-1; (10) volume loading test: 250 ml of 4% albumin was infused over 10 min. At each time point, hemodynamic parameters were monitored using pulse contour analysis. A positive volume response was defined as an increase of at least 15% in SVI on pulse contour monitoring from baseline-4 after the volume loading test. The receiver operating characteristic curves were performed for ΔSVI.ResultsIn this study, 36 patients were included for analysis, and of these, 15 patients (42%) were volume-responsive. TRENDSUPINE-induced ΔSVI (ΔSVISUPINE-TREND), TRENDrTREND-induced ΔSVI (ΔSVIrTREND-TREND) and PLR-induced ΔSVI (ΔSVIPLR) were 6%, 16%, and 11%, respectively (ΔSVISUPINE-TREND vs. ΔSVIrSUPINE-TREND, p < 0.001; ΔSVISUPINE-TREND vs. ΔSVIPLR, p < 0.05). The R2 values of the linear regression between ΔSVISUPINE-TREND, ΔSVIrTREND-TREND, ΔSVIPLR and volume loading test-induced ΔSVI were 0.14, 0.32, and 0.43, respectively (all p < 0.001). Furthermore, the area under the receiver operating characteristic curve for predicting volume responsiveness was 0.78 [95% confidence interval (CI), 0.59-0.92], 0.88 (95%CI, 0.75-0.96), and 0.83 (95%CI, 0.61-0.95) for TRENDSUPINE, TRENDrTREND, and PLR-induced ΔSVI, respectively, with no statistically significant difference among them. The sensitivity and specificity for predicting volume responsiveness were 93% and 67% for ΔSVISUPINE-TREND at 4% cutoff, 87% and 76% for ΔSVIrTREND-TREND at 13% cutoff, and 73% and 86% for ΔSVIPLR at 11% cutoff.ConclusionsThe Trendelenburg position (TRENDSUPINE and TRENDrTREND)-induced and PLR-induced percentage changes in SVI were similar in their ability to predict volume responsiveness in mechanically ventilated patients in the ICU. Considering that TRENDrTREND induced greater percentage changes in SVI, it is preferentially recommended as a reasonable alternative to PLR for predicting volume responsiveness in certain clinical scenarios.Trial RegistrationChiCTR2300067694. Registered on January 18, 2023.© 2025. The Author(s).

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