• Javiera Martinez-Gutierrez, María Gabriela Soto, Andrea Rioseco, Catalina Bienzobas, Madeline Fowler, Gonzalo Ulloa, Mauricio Soto, Jon David Emery, and Klaus Puschel.
• Department of Family and Community Medicine, School of Medicine, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, Macul, Santiago, Región Metropolitana, 7820436, Chile.
• Fam Pract. 2025 Feb 7; 42 (2).

BackgroundCancer is a major global cause of death, and primary care is crucial for cancer prevention and early detection. However, there is conflicting information on the effectiveness, implementation, and sustainability of cancer control interventions in primary care.ObjectiveThis study aimed to summarize the evidence for cancer control in primary care, focussing on identifying relevant factors for implementation and sustainability.Study Setting And DesignWe conducted a narrative, mixed-methods review of systematic reviews, guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Four databases were screened, and two independent reviewers selected studies reporting on cancer prevention, screening, or early detection in primary or community settings. We analysed findings using the extended Reach-Effectiveness-Adopt-Implementation-Maintenance (RE-AIM) Framework.Principal FindingsFrom the 37 reviews that met the inclusion criteria, 6 focussed on primary prevention, 23 on screening, and 12 on early detection. Most reviews (78%) addressed intervention effectiveness, such as HPV vaccination, tobacco cessation, and cervical, breast, and colorectal screening. One-third of the reviews mentioned adoption and implementation factors, including barriers and facilitators to the implementation of cancer screening programs. Only one review addressed maintenance and sustainability factors, exploring continuous resources and funding strategies.ConclusionWhile numerous interventions are effective for cancer prevention and detection in primary care, literature on implementation and sustainability strategies is lacking. Focusing on continuous resources and funding for cancer strategies in primary care may aid sustainability. Future research should prioritize reporting on implementation and sustainability factors to enhance cancer prevention and control in primary care settings.© The Author(s) 2025. Published by Oxford University Press.

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