• Am. J. Respir. Crit. Care Med. · Oct 2011

    Guideline

    CDC/NIH Workshop. Tuberculosis biomarker and surrogate endpoint research roadmap.

    • Thomas B Campbell, Payam Nahid, Kathleen D Eisenach, Jussi Saukkonen, William R Mac Kenzie, Patrick P J Phillips, Janet Andersen, Erin Bliven-Sizemore, John T Belisle, W Henry Boom, Annie Luetkemeyer, Richard Hafner, Jeffrey L Lennox, Mamodikoe Makhene, Susan Swindells, M Elsa Villarino, Marc Weiner, Constance Benson, William Burman, National Institutes of Health, and Centers for Disease Control and Prevention.
    • Division of Pulmonary and Critical Care, Curry International Tuberculosis Center, San Francisco General Hospital, University of California-San Francisco, CA 94110, USA. pnahid@ucsf.edu
    • Am. J. Respir. Crit. Care Med.. 2011 Oct 15;184(8):972-9.

    AbstractThe Centers for Disease Control and Prevention and National Institutes of Health convened a multidisciplinary meeting to discuss surrogate markers of treatment response in tuberculosis. The goals were to assess recent surrogate marker research and to provide specific recommendations for (1) the qualification and validation of biomarkers of treatment outcome; (2) the standardization of specimen and data collection for future clinical trials, including a minimum set of samples and collection time points; and (3) the creation ofa specimen repository to support biomarker testing. This article summarizes these recommendations and provides a roadmap for their implementation.

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