• Br J Anaesth · Dec 2009

    Randomized Controlled Trial Multicenter Study

    Prospective randomized controlled multi-centre trial of cuffed or uncuffed endotracheal tubes in small children.

    • M Weiss, A Dullenkopf, J E Fischer, C Keller, A C Gerber, and European Paediatric Endotracheal Intubation Study Group.
    • Department of Anaesthesia, University Children's Hospital Zurich, Zurich, Switzerland. markus.weiss@kispi.uzh.ch
    • Br J Anaesth. 2009 Dec 1; 103 (6): 867-73.

    BackgroundThe use of cuffed tracheal tubes (TTs) in small children is still controversial. The aim of this study was to compare post-extubation morbidity and TT exchange rates when using cuffed vs uncuffed tubes in small children.MethodsPatients aged from birth to 5 yr requiring general anaesthesia with TT intubation were included in 24 European paediatric anaesthesia centres. Patients were prospectively randomized into a cuffed TT group (Microcuff PET) and an uncuffed TT group (Mallinckrodt, Portex, Rüsch, Sheridan). Endpoints were incidence of post-extubation stridor and the number of TT exchanges to find an appropriate-sized tube. For cuffed TTs, minimal cuff pressure required to seal the airway was noted; maximal cuff pressure was limited at 20 cm H(2)O with a pressure release valve. Data are mean (SD).ResultsA total of 2246 children were studied (1119/1127 cuffed/uncuffed). The age was 1.93 (1.48) yr in the cuffed and 1.87 (1.45) yr in the uncuffed groups. Post-extubation stridor was noted in 4.4% of patients with cuffed and in 4.7% with uncuffed TTs (P=0.543). TT exchange rate was 2.1% in the cuffed and 30.8% in the uncuffed groups (P<0.0001). Minimal cuff pressure required to seal the trachea was 10.6 (4.3) cm H(2)O.ConclusionsThe use of cuffed TTs in small children provides a reliably sealed airway at cuff pressures of

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