• Mediators of inflammation · Feb 2005

    The differential diagnostic values of cytokine levels in pleural effusions.

    • Saadet Akarsu, A Nese Citak Kurt, Yasar Dogan, Erdal Yilmaz, Ahmet Godekmerdan, and A Denizmen Aygun.
    • Department of Pediatrics, Medical faculty, Firat university, Elazig, Turkey. akarsu@firat.edu.tr
    • Mediators Inflamm. 2005 Feb 24;2005(1):2-8.

    AbstractThe aim is to examine whether the changes in pleural fluid interleukin (IL)-1beta, IL-2, IL-6, and IL-8 levels were significant in differential diagnosis of childhood pleural effusions. IL-1beta, IL-2, IL-6, and IL-8 levels in pleural fluids of all 36 patients were measured. The levels of IL-1beta, IL-2, IL-6, and IL-8 in pleural fluids were statistically significantly higher in the transudate group compared with those of the exudate group. The levels of IL-1 beta, IL-6, and IL-8 were also found to be statistically significantly higher in the empyema group compared with both the parapneumonic and the tuberculous pleural effusion groups. The levels of IL-2 and IL-6 were detected to be statistically significantly higher in the tuberculous pleural effusion group in comparison with those of the parapneumonic effusion group. The results showed that pleural fluids IL-1beta, IL-2, IL-6, and IL-8 could be used in pleural fluids exudate and transudate distinction.

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