• Jacinta J Maas, Bart F Geerts, Paul C M van den Berg, Michael R Pinsky, and Jos R C Jansen.
• Department of Intensive Care Medicine, Leiden University Medical Center, Leiden, The Netherlands. j.j.maas@lumc.nl
• Crit. Care Med. 2009 Mar 1;37(3):912-8.

ObjectiveTo measure the relationship between blood flow and central venous pressure (Pcv) and to estimate mean systemic filling pressure (Pmsf), circulatory compliance, and stressed volume in patients in the intensive care unit.DesignIntervention study.SettingIntensive care unit of a university hospital.PatientsTwelve mechanically ventilated postoperative cardiac surgery patients.InterventionsInspiratory holds were performed during normovolemia in supine position (baseline), relative hypovolemia by placing the patients in 30 degree head-up position (hypo), and relative hypervolemia by volume loading with 0.5 L colloid (hyper).Measurements And Main ResultsWe measured the relationship between blood flow and Pcv using 12-second inspiratory-hold maneuvers transiently increasing Pcv to three different steady-state levels and monitored the resultant blood flow via the pulse contour method during the last 3 seconds. The Pcv to blood flow relation was linear for all measurements with a slope unaltered by relative volume status. Pmsf decreased with hypo and increased with hyper (18.8 +/- 4.5 mm Hg, to 14.5 +/- 3.0 mm Hg, to 29.1 +/- 5.2 mm Hg [baseline, hypo, hyper, respectively, p < 0.05]). Baseline total circulatory compliance was 0.98 mL x mm Hg x kg and stressed volume was 1677 mL.ConclusionsPmsf can be determined in intensive care patients with an intact circulation with use of inspiratory pause procedures, making serial measures of circulatory compliance and circulatory stressed volume feasible.

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