• Masayo Morioka, Tomoyuki Kumatoriya, Takeshi Morooka, Keisuke Watanabe, Junko Tayama, Toshiyuki Shimomura, and Hitoshi Furuya.
• Nara Emergency and Critical Care Medical Center, Nara Prefectural Nara Hospital, Nara 631 0846.
• Masui. 2006 Jan 1;55(1):55-8.

BackgroundPropofol and droperidol decrease the incidence of postoperative nausea and vomiting (PONV). We investigated the incidence of PONV after total intravenous anesthesia (TIVA) with propofol alone versus combined use of droperidol and propofol.MethodsEighty three patients, who had undergone laparoscopic gynecologic surgery with TIVA using propofol and fentanyl, were retrospectively evaluated whether droperidol had affected the incidence of early (up to six hours postoperatively) and late (6-24 hours postoperatively) PONV. Group D (46 patients) received droperidol intravenously at the end of surgery. Group N (37 patients) received no droperidol.ResultsThe incidences of early nausea were 27% in Group N and 4% in Group D (P<0.01). The incidences of early vomiting were 0% in Group N and 8% in Group D. The incidences of late nausea were 14% in Group N and 13% in Group D. The incidences of late vomiting were 3% in Group N and 7% in Group D.ConclusionsDroperidol was useful in reducing the incidence of early nausea and vomiting after total intravenous anesthesia with propofol and fentanyl in the patients undergoing laparoscopic surgery.

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