• Immunity · Sep 2013

    Review

    Mechanisms of NOD-like receptor-associated inflammasome activation.

    • Haitao Wen, Edward A Miao, and Jenny P-Y Ting.
    • The Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
    • Immunity. 2013 Sep 19;39(3):432-41.

    AbstractA major function of a subfamily of NLR (nucleotide-binding domain, leucine-rich repeat containing, or NOD-like receptor) proteins is in inflammasome activation, which has been implicated in a multitude of disease models and human diseases. This work will highlight key progress in understanding the mechanisms that activate the best-studied NLRs (NLRP3, NLRC4, NAIP, and NLRP1) and in uncovering inflammasome NLRs.Copyright © 2013 Elsevier Inc. All rights reserved.

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