• J Med Assoc Thai · Dec 2007

    Randomized Controlled Trial Clinical Trial

    A comparison of propofol-LCT with propofol-LCT/MCT on pain of injection.

    • Petchara Sundarathiti, Nuanjai Boonthom, Theerawat Chalacheewa, Porpimon Jommaroeng, and Wanadee Rungsithiwan.
    • Department of Anesthesiology, Ramathibodi Hospital, Faculty of Medicine, Mahidol University, Bangkok 10400, Thailand.
    • J Med Assoc Thai. 2007 Dec 1;90(12):2683-8.

    BackgroundPropofol-Lipuro 1% is consisting of long-chain triglycerides (LCT) and medium-chain triglycerides (MCT) that have been reported to reduce injection pain.ObjectiveTo compare the incidence and intensity of injection pain with 1% Propofol-LCT with 1% Propofol-LCT/MCT in female populations for minor surgery under total intravenous anesthesia (TIVA).Material And MethodOne hundred and ten female patients were double-blind randomized into two groups. Group long-chain triglycerdes (L) received 1% propofol-LCT while group long-chain triglycerides/medium-chain triglycerides (L/M) received 1% propofol-LCT/MCT. All patients received no benzodiazepine premedication and fentanyl 1 microg/kg was given 3 minutes before propofol injection. The propofol 1 mg/kg was manually injected at 0.5 mL/sec. The verbal rating score (VRS 0-10) was recorded on pain of injection. VRS > 4 indicates a significant response to pain.ResultsThere was a significantly greater incidence and intensity of injection pain in group L compared with group L/M (p < 0.001 and p = 0.013 respectively).ConclusionsPropofol-LCT/MCT is superior to propofol-LCT on reducing pain of injection.

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