• Crit Care · Jan 2011

    Identifying critically ill patients who benefit the most from nutrition therapy: the development and initial validation of a novel risk assessment tool.

    • Daren K Heyland, Rupinder Dhaliwal, Xuran Jiang, and Andrew G Day.
    • Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, ON, Canada. dkh2@queensu.ca
    • Crit Care. 2011 Jan 1; 15 (6): R268.

    IntroductionTo develop a scoring method for quantifying nutrition risk in the intensive care unit (ICU).MethodsA prospective, observational study of patients expected to stay > 24 hours. We collected data for key variables considered for inclusion in the score which included: age, baseline APACHE II, baseline SOFA score, number of comorbidities, days from hospital admission to ICU admission, Body Mass Index (BMI) < 20, estimated % oral intake in the week prior, weight loss in the last 3 months and serum interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) levels. Approximate quintiles of each variable were assigned points based on the strength of their association with 28 day mortality.ResultsA total of 597 patients were enrolled in this study. Based on the statistical significance in the multivariable model, the final score used all candidate variables except BMI, CRP, PCT, estimated percentage oral intake and weight loss. As the score increased, so did mortality rate and duration of mechanical ventilation. Logistic regression demonstrated that nutritional adequacy modifies the association between the score and 28 day mortality (p = 0.01).ConclusionsThis scoring algorithm may be helpful in identifying critically ill patients most likely to benefit from aggressive nutrition therapy.

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