• Internal medicine · Oct 2004

    Case Reports

    Multiple brain tumors of diffuse large B cell lymphoma in a patient with Waldenström's macroglobulinemia/ lymphoplasmacytic lymphoma: PCR and DNA sequence analysis show evidence of differences in clonality of the two B cell malignancies.

    • Kana Tojo, Takeshi Hattori, Toshiro Ito, Naoko Asano, Kenji Sano, Takefumi Suzuki, and Keiko Maruyama.
    • Department of Neurology, Suwa Red Cross Hospital, Nagano.
    • Intern. Med. 2004 Oct 1;43(10):990-6.

    AbstractMultiple brain tumors of diffuse large B cell lymphoma (DLBL) were observed in a 75-year-old man with Waldenström's macroglobulinemia (WM). Paravertebral and multiple subcutaneous nodules occurred in succession and he died 4 months after onset. We investigated B cell monoclonality by means of polymerase chain reaction (PCR) analysis and sequencing of the immunoglobulin heavy chain of paraffin-embedded sections. The PCR product of the brain tumors showed a different rearrangement pattern from those of the other sections. The co-occurrence of DLBL with WM is rare, and some investigators have examined the clonality of the two malignancies. This case is important because DLBL brain tumors co-occurred with WM, enabling us to prove that DLBL and WM have different clonality.

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