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Eur. J. Heart Fail. · Feb 2012
ReviewDetection, monitoring, and management of trastuzumab-induced left ventricular dysfunction: an actual challenge.
- Carlo G Tocchetti, Gianluca Ragone, Carmela Coppola, Domenica Rea, Giovanna Piscopo, Stefania Scala, Claudia De Lorenzo, Rosario V Iaffaioli, Claudio Arra, and Nicola Maurea.
- Division of Cardiology, National Cancer Institute, Sen. Pascale Foundation, Naples, Italy. cgtocchetti@iol.it
- Eur. J. Heart Fail. 2012 Feb 1;14(2):130-7.
AbstractThe antibody trastuzumab, targeted to inhibit the signalling of ErbB2, a tyrosine kinase receptor overexpressed in 20-30% of breast cancers, improves the prognosis in women affected by this tumour, but produces cardiotoxicity, since ErbB2 is also involved in myocardial homeostasis. In this review, we discuss the pathophysiology of trastuzumab cardiomyopathy and the complex interplay between ErbB2 inhibition and anthracyclines, and we focus on the actual challenges of detecting, monitoring, and managing trastuzumab cardiotoxicity: the research of new, sensitive markers of early trastuzumab toxicity, before the ejection fraction is reduced, is an active field of research.
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