• Archives of virology · May 2015

    Molecular and serological evidence for Seoul virus in rats (Rattus norvegicus) in Zhangmu, Tibet, China.

    • Tingsong Hu, Quanshui Fan, Xiaobing Hu, Bo Deng, Gang Chen, Liangqi Gu, Ming Li, Ying Zheng, Guihong Yuan, Wei Qiu, Xiaomei Jiang, and Fuqiang Zhang.
    • Centre for Disease Control and Prevention, Chengdu Military Region, 168 Daguan Road, Kunming, 650032, China, htsong2001@sina.com.
    • Arch. Virol. 2015 May 1;160(5):1353-7.

    AbstractWe report the detection of a virus, tentatively identified as Seoul virus (SEOV), from a rat (Rattus norvegicus) collected in the city of Zhangmu, Tibet. SEOV RNA was detected in lung tissue by reverse transcription (RT)-PCR, followed by sequencing. Serum samples collected from Zhangmu were positive for SEOV-specific antibodies (indirect fluorescent antibody test that used SEO antigen). Sequencing and phylogenetic analysis of partial L and S sequences together with serology results suggest that the Zhangmu01 hantavirus is an isolate of SEOV, that hantaviruses circulate in Tibet, and that rats may act as natural reservoirs for the virus.

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