• Eduardo B Saad, Nassir F Marrouche, Cynthia P Saad, Edward Ha, Dianna Bash, Richard D White, John Rhodes, Lourdes Prieto, David O Martin, Walid I Saliba, Robert A Schweikert, and Andrea Natale.
• The Cleveland Clinic Foundation, Desk F26, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA.
• Ann. Intern. Med. 2003 Apr 15;138(8):634-8.

BackgroundPulmonary vein isolation is a new, effective curative procedure for selected patients with atrial fibrillation. Pulmonary vein stenosis is a potential complication and may lead to symptoms that are often underrecognized.ObjectiveTo describe the clinical course and symptoms associated with pulmonary vein stenosis developing after ablation in the pulmonary veins.DesignRetrospective study.SettingTertiary care referral center.Patients335 patients referred for catheter ablation of drug-refractory atrial fibrillation.InterventionPulmonary vein electrical isolation using radiofrequency catheter ablation.MeasurementsThree months after ablation, patients underwent routine screening for pulmonary vein stenosis with spiral computed tomography. Screening was considered earlier if symptoms suggestive of stenosis developed and was repeated at 6 and 12 months if any pulmonary vein narrowing was observed. Pulmonary vein angiography and dilatation were offered to patients with severe (>70%) stenosis.ResultsSevere pulmonary vein stenosis was detected in 18 patients (5% [95% CI, 3.2% to 8.4%]) a mean (+/-SD) of 5.2 +/- 2.6 months after ablation. Eight of these 18 patients (44%) were asymptomatic, but 8 (44%) reported shortness of breath, 7 (39%) reported cough, and 5 (28%) reported hemoptysis. Radiologic abnormalities were present in 9 patients (50%) and led to diagnoses of pneumonia (4 patients), lung cancer (1 patient), and pulmonary embolism (2 patients). Pulmonary vein stenosis was not considered in any patient during the initial work-up. Dilatation of the affected vein was performed in 12 patients. Postintervention lung perfusion scans revealed significant improvement in lung flow.ConclusionsSevere pulmonary vein stenosis after catheter ablation of atrial fibrillation is associated with respiratory symptoms that frequently mimic more common diseases, often leading to erroneous diagnostic and therapeutic procedures. Awareness of this syndrome is important for proper and prompt management.

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