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Case Reports
Administration of depolarizing muscle relaxants after non-depolarizer reversal: when is it safe?
- J A De Roubaix.
- S. Afr. Med. J. 1982 Apr 17;61(16):583-4.
AbstractIn the light of studies on the duration of action and pharmacokinetics of intravenous neostigmine, it is recommended that, depending upon the dosage administered, at least 1 hour should elapse before a depolarizer can safely be given after neuromuscular reversal with neostigmine, and at least 90 - 120 minutes after reversal with physostigmine. It is suggested that a diluted test dose of depolarizer be given first, and its effect monitored with a peripheral nerve stimulator because fasciculations will not occur.
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