• Sci. STKE · Jul 2005

    Interleukin-13 (IL-13) pathway.

    • Ann Kelly-Welch, Erica M Hanson, and Achsah D Keegan.
    • Program in Oncology, Marlene and Stewart Greenebaum Cancer Center and Department of Microbiology and Immunology, University of Maryland, Baltimore, USA.
    • Sci. STKE. 2005 Jul 19;2005(293):cm8.

    AbstractInterleukin-13 (IL-13), like IL-4, is a cytokine produced by T(H)2 type helper T cells in response to signaling through the T cell antigen receptor and by mast cells and basophils upon cross-linkage of the high-affinity receptor for immunoglobulin E (IgE). It is also produced by activated eosinophils. IL-13 induces many of the same responses as IL-4 and shares a receptor subunit with IL-4. IL-13 has been implicated in airway hypersensitivity and mucus hypersecretion, inflammatory bowel disease, and parasitic nematode expulsion.

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