• Internal medicine · May 2005

    Case Reports

    Platypnea-orthodeoxia syndrome combined with multiple congenital heart anomalies.

    • Yasuhiro Nagayoshi, Kensuke Toyama, Hiroaki Kawano, Ikuo Misumi, Shinzo Miyamoto, Sunao Kojima, Tomohiro Sakamoto, Michihiro Yoshimura, and Hisao Ogawa.
    • Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Japan.
    • Intern. Med. 2005 May 1;44(5):453-7.

    AbstractA 71-year-old woman was admitted for paralysis on the left side of her body. She developed dyspnea and hypoxemia after admission. Although pulmonary embolism was suspected, hypoxemia and dyspnea occurred repeatedly in spite of anticoagulation therapy. Transesophageal echocardiography revealed a patent foramen ovale (PFO), an atrial septal aneurysm (ASA), and a right-to-left shunt that appeared in an upright position. She was diagnosed with platypnea-orthodeoxia syndrome. Moreover, cardiac catheterization showed congenital anomalies, such as unroofed coronary sinus, partial anomalous pulmonary venous return and persistent left superior vena cava. Simple surgical closure of the ASA and PFO improved all of her symptoms.

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