• S Westaby, K Saatvedt, S White, T Katsumata, W van Oeveren, N K Bhatnagar, S Brown, and P W Halligan.
• Oxford Heart Centre, John Radcliffe Hospital, Oxford, United Kingdom.
• J. Thorac. Cardiovasc. Surg. 2000 Jan 1;119(1):132-7.

ObjectivesOver the past decade, the glial protein S-100beta has been used to detect cerebral injury in a number of clinical settings including cardiac surgery. Previous investigations suggest that S-100beta is capable of identifying patients with cerebral dysfunction after cardiopulmonary bypass. Whether detection of elevated levels S-100beta reflects long-term cognitive impairment remains to be shown. The present study evaluated whether perioperative release of S-100beta after coronary artery operations with cardiopulmonary bypass could predict early or late neuropsychologic impairment.MethodsA total of 100 patients undergoing elective coronary bypass without a previous history of neurologic events were prospectively studied. To exclude noncerebral sources of S-100beta, we did not use cardiotomy suction or retransfusion of shed mediastinal blood. Serial perioperative measurements of S-100beta were performed with the use of a new sensitive immunoluminometric assay up to 8 hours after the operation. Patients underwent cognitive testing on a battery of 11 tests before the operation, before discharge from the hospital, and 3 months later.ResultsNo significant correlation was found between S-100beta release and neuropsychologic measures either 5 days or 3 months after the operation.ConclusionDespite using a sensitive immunoluminometric assay of S-100beta, we found no evidence to support the suggestion that early release of S-100beta may reflect long-term neurologic injury capable of producing cognitive impairment.

29 keywords...

hide…